Physiology, biomechanics and aging

The research produced by YU-CARE members and associates along the theme of the physiology and biomechanics of aging are impactful at the individual, organizational, and societal levels. Research spans from topics including:

  • Pain and Aging;
  • Physiology & Biomechanics and Aging; and
  • Physical Activity and Aging.

Please click the hyperlink (content italicized and underlined in red) at each citation to find each article or abstract.

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Pain and Aging

  1. Gauthier, L.R., Dworkin, R.H., Warr, D., Pillai Riddell, R., Macpherson, A., Rodin, G., Zimmermann, C., Librach, S.L., Moore, M., Shepherd, F.A., & Gagliese, L. (April, 2018). Age-related patterns in cancer pain and its psychosocial impact: investigating the role of variability in physical and mental health quality of life. Pain Medicine, 19(4):658-676. (6 citations)
  2. Goodall, S., Gauthier, L.R., Li, M., Connor, M., Chan, V., Easson, A., Gagliese, L. (May, 2018). The impact of inflammatory cytokines and biopsychosocial factors on acute pain after breast cancer surgery. 39th Annual Scientific Meeting of the Canadian Pain Society, Montreal, QC. Canadian Journal of Pain, 2(1): A165.
  3. Gagliese, L., Gauthier, L. R., Narain, N., & Freedman, T. (2018). Pain, aging and dementia: Towards a biopsychosocial model. Progress in Neuro-Psychopharmacology and Biological Psychiatry87, 207-215.
  4. Gauthier, L. R., Dworkin, R. H., Warr, D., Riddell, R. P., Macpherson, A. K., Rodin, G., ... Gagliese, L. (2017). Age-Related Patterns in Cancer Pain and Its Psychosocial Impact: Investigating the Role of Variability in Physical and Mental Health Quality of Life. Pain Medicine, 19(4), 658-676.
  5. Gagliese, L., Gauthier, L. R., Narain, N., & Freedman, T. (2017). Pain, aging and dementia: Towards a biopsychosocial model. Progress in Neuro-Psychopharmacology and Biological Psychiatry.
  6. Mah, K.*, Tran, K.T.*, Gauthier, L.R., Rodin, G., Zimmermann, C., Warr, D.G., Librach, S.L., Moore, M.J., Shepherd, F.A., & Gagliese, L. (2017). Psychometric evaluation of the Pain Attitudes Questionnaire-Revised for younger and older people with advanced cancer. Submitted to The Journal of Pain. *Co-first authors
  7. Gauthier, L.R., Dworkin, R.H., Warr, D., Pillai Riddell, R., Macpherson, A., Rodin, G., Zimmermann, C., Librach, S.L., Moore, M., Shepherd, F.A., & Gagliese, L. (2017) Age-related patterns in cancer pain and its psychosocial impact: investigating the role of variability in physical and mental health quality of life. Submitted to Pain Medicine.
  8. Hochman, J.R., Davis, A.M., Elkayam J., Gagliese, L., & Hawker G.A., (2013) Neuropathic pain symptoms on the Modified painDETECT correlate with signs of central sensitization in knee osteoarthritis.  Osteoarthritis and Cartilage 21(9) S1: 1236-1242.
  9. Gagliese, L., Katz, L., Gibson, M., Clark, A. J., Lussier, D., Gordon, A., & Salter, M. W. (2012). A brief educational intervention about pain and aging for older members of the community and health care workers. Journal of Pain13(9), 849-856.
  10. Gagliese, L., & Melzack, R. (2003). Age-related differences in the qualities but not the intensity of chronic pain.  Pain, 104, 597-608.
  11. Gagliese, L., & Melzack, R. (1997). Chronic pain in elderly people. Pain, 70, 3-14
  12. Gagliese, L., & Melzack, R. (1997). Lack of evidence for age differences in pain beliefs. Pain Research and Management, 2, 19-28. [PDF]
  13. Gagliese, L., & Melzack, R. (1997). Age differences in the quality of chronic pain. Pain Research and Management, 2, 157-162. [PDF]
  14. Meisner, B. A., Linton, V., Séguin, A., & Spassiani, N. A. (2017). Examining chronic disease, pain-related impairment, and physical activity among middle-aged and older adults in Canada: Implications for current and future aging populations. Topics in Geriatric Rehabilitation, 33(3), 182-192.
  15. Mah, K., Tran, K. T., Gauthier, L. R., Rodin, G., Zimmermann, C., Warr, D., ... & Gagliese, L. (2018). Do Correlates of Pain-Related Stoicism and Cautiousness Differ in Younger and Older People With Advanced Cancer?. Journal of Pain, 19(3), 301-316.
  16. Gagliese, L. (2009). Pain and aging: The emergence of a new subfield of pain research.  Journal of Pain 10(4):343-53.
  17. Gagliese, L., Jovellanos, M., Zimmermann, C., Shobbrook, C., Warr, D., Rodin, G. (2009) Age-related patterns in adaptation to cancer pain: A mixed-method study. Pain Medicine 10(6): 1050-1061.
  18. Gagliese, L., Gauthier, L., & Rodin, G.M., (2007). Cancer pain and depression: A systematic review of age-related patterns.  Pain Research and Management, 20(3), 205-211
  19. Gagliese, L., Weizblit, N., Ellis, W. & Chan, V. (2005). The measurement of postoperative pain: A comparison of intensity scales in younger and older surgical patients. Pain, 117, 412-20.

Physiology & Biomechanics of Aging

  1. Erlich, A. T. and D. A. Hood. (2019). Mitophagy regulation in skeletal muscle: Effect of endurance exercise and age. Journal of Science in Sport and Exercise.
  2. Hood,A., J.M. Memme, A.N. Oliveira and M. Triolo. (20190. Maintenance of skeletal muscle mitochondria in health, exercise, and aging. Ann. Rev. Physiol. 81:19-41.
  3. Chen, C. C., Erlich, A. T., Crilly, M. J., & Hood, D. A. (2018). Parkin is required for exercise-induced mitophagy in muscle: Impact of aging. American Journal of Physiology-Endocrinology and Metabolism, 315(3).
  4. Street BD, Adkin A, Gage W. (2018). Reported balance confidence and movement reinvestment of younger knee replacement patients are more like younger healthy individuals, than older patients. Gait and posture. 61:130-134.
  5. Carter, H. N., Kim, Y., Erlich, A. T., Zarrin-Khat, D., & Hood, D. A. (2018). Autophagy and mitophagy flux in young and aged skeletal muscle following chronic contractile activity. The Journal of Physiology, 596(16), 3567-3584.
  6. Street, B. D., & Gage, W. (2017). After total knee replacement younger patients demonstrate superior balance control compared to older patients when recovering from a forward fall. Clinical Biomechanics44, 59-66.
  7. Huang J.H., A.-M. Joseph, V. Ljubicic, S. Iqbal, and D.A. Hood. Effect of age on the processing and import of matrix-destined mitochondrial proteins in skeletal muscle.  Gerontol. A Biol. Sci. Med. Sci. 65:138-46, 2010.
  8. Scime, A., Desrosiers, J., Trensz, F., Palidwor, G. A., Caron, A. Z., Andrade-Navarro, M. A., & Grenier, G. (2010). Transcriptional profiling of skeletal muscle reveals factors that are necessary to maintain satellite cell integrity during ageing. Mechanisms of Ageing and Development131, 9-20. [PDF]
  9. Kuk, J. l., Saunders, T. J., Davidson, L. E., & Ross, R. (2009). Age-related changes in total and regional fat distribution. Ageing Research Reviews8(4), 339-348.
  10. Kuk, J. L., & Arden, C. I. (2009). Influence of age on the association between various measures of obesity and all-cause mortalityAmerican Geriatrics Society57, 2077-2084.
  11. Kuk, J. L., Davidson, L. E., Hudson, R., Kilpatrick, K., Bacskai, K., & Ross, R. (2008). Association between dietary fat intake, liver fat, and insulin sensitivity in sedentary, abdominally obese, older men. Applied Physiology, Nutrition, and Metabolism32(2), 239-245.
  12. Kuk, J. L., Lee, S., Heymsfield, S. B., & Ross, R. (2005). Waist circumference and abdominal adipose tissue distribution: influence of age and sex. American Society for Clinical Nutrition81, 1330-1334.
  13. Brown, L., Gage, W., Polych, M., Sleik, R., & Winder, T. (2002). Central set influences on gait: Age-dependent effects of postural threat. Experimental Brain Research145(3), 286-296.

Physical Activity and Aging

  1. Dixon, J., Horton, S., Chittle, L., & Baker, J. (2020). Relative age effects in sport: International perspectives. Routledge/Taylor and Francis.
  2. Hood,A., J.M. Memme, A.N. Oliveira and M. Triolo.(2019). Maintenance of skeletal muscle mitochondria in health, exercise, and aging. Ann. Rev. Physiol. 81:19-41.
  3. Chen, C.C.W., A. T. Erlich, M. J. Crilly and A. Hood.(2018). Parkin is required for exercise-induced mitophagy in muscle: impact of aging. Am. J. Physiol. (Endocrin. Metab.) 315:E404-E415.
  4. Chen C.C.W., A.T. Erlich and A. Hood.(2018). Role of Parkin and endurance training on mitochondrial turnover in skeletal muscle. Skelet. Muscle 8:10.
  5. Kim, Y., Triolo, M., & Hood, D. A. (2017). Impact of Aging and Exercise on Mitochondrial Quality Control in Skeletal Muscle. Oxidative Medicine and Cellular Longevity, 2017, 1-16.
  6. Carter, H. N., Chen, C. C., & Hood, D. A. (2015). Mitochondria, muscle health, and exercise with advancing age. Physiology30(3), 208-223.
  7. Brown, R. E., Riddell, M. C., Macpherson, A. K., Canning, K. L., & Kuk, J. L. (2013). The association between frequency of physical activity and mortality risk across the adult age span. Journal of Health and Aging25(2), 803-814.
  8. Meisner, B.A., Dogra, S., Logan, A.J., Baker, J., & Weir, P.L. (2010). Do or decline: Comparing the effects of physical inactivity on biopsychosocial components of successful aging. Journal of Health Psychology, 15, 688-696.
  9. Davidson LE, Hudson R, Kilpatrick K, et al. Effects of Exercise Modality on Insulin Resistance and Functional Limitation in Older Adults: A Randomized Controlled Trial. Arch Intern Med. 2009;169(2):122–131.
  1. Baker, J., Meisner, B., Logan, J. Kungl, A.M., & Weir, P. (2009). Physical activity and successful aging in Canadian seniors. Journal of Aging and Physical Activity, 17, 223-235.